Purification of Ricin: Figure 1C and 1d, not clear if they are from pure Ricin or extract. If they are not from pure Ricin, it is not clear what value they are adding to the manuscript. So, either explain clearly or remove.
Pilot study: Effective concentration of Ricin used should be mentioned in the text as well as in the figure and figure legends. In figure 2 the all the structures should be indicated with proper arrowhead and clearly written. In current manuscript it is difficult to compare the features and make any judgement.
Assessment of hair follicle dystrophy: Figure 3B, How the dystrophy score is calculated? Figure 3C, this is very complicated to follow. Should we compare panel a with panel k? Please label all the panels within the figure in a comprehensive way. Also, indicate the structures within a panel that readers should focus on. Authors mentioned in text about differential structures like ectopic melanin granules, follicular and hair shaft distortion and irregular diameter of hair bulbs, but none are pointed out in the images, so it is not possible to draw any conclusion at this time.
In vitro organ culture : What does the number 40 mean in R40 and rest in Figure 4A? Again, all the panels should be labeled clearly in Figure 4B. What is the rationale for using DAPI?