Peer-reviewed by 2 reviewers with median rating of 14.5/20. Review process was triple-blinded.
Round 1 (14/20)
Round 2 (14.5/20)
Conceptual advance and Impact5.5
A very neat single-observation study. One idea, several experiments, and one, firm conclusion providing yet another piece of knowledge about 14-3-3s. Tech note: "logarithmic phase" is a rather imprecise term; gorwth curves and exact OD points would be better.
Conceptual advance and Impact7.5
This is quite a nice single observation, and actually could develop into a more substantial story. Well worth reporting.
the authors should include statistics/p-values (student t-test) at least for panels d and j where the differences are not very large.
Results & Discussion
The authors should better explain why they picked only GEA1, and not any other GEF (or even GEA2) for the rescue experiment. At least better explain the regulation by AMPK, which makes it a potential good candidate to test.
I think a little more conjecture is just fine here!