- The major issue with this Matters manuscript is the method: the authors did not generate their own data but used ontology data from EMOUSE and GUDMAP, and counted. Therefore we believe that the technical quality is not sufficient for Matters.
- A suggestion to make it of higher impact: they could (have) show(n) whether c. elegans fits in Waddington's theory. One of the only organisms of which the whole ontology is known is c. elegans.
- We would like to refer back to our comment about the supplementary figure, where we suggested to show the raw data used for analysis.