I would be more enthusiastic if the authors devoted a little more text to the physiological importance of S-sulfhydration of rhodanese domains. Simply stating " The ubiquity of the rhodanese domain and its occurrence in a wide variety of protein families indicates that it has diverse roles in physiology" is hardly sufficient. What are the diverse roles? What is the impact of the observation of destabilization? I realize the function of YgaP is unknown, but if rhodanese domains are important, surely the authors could speculate.