Peer-reviewed by 2 reviewers with median rating of 16.5/20. Review process was triple-blinded.
Round 1 (14.5/20)
Round 2 (16.5/20)
Conceptual advance and Impact5
While this paper does not have novelty. It reproduces the previous finding of lymphatic vessels in the human brain. I would highly recommend the author change the title to reflect this point.
Conclusions should emphasize that their work provides more example that detection of mLVs can be done in vivo using MRI.
I would change the title to reflect that this work provide additional of meningeal lymphatic vessels in human at hires MRI. Something like "In vivo visualization of meningeal lymphatic vessels in human with high-resolution 3T MRI"
In Panel A, B, C lymphatic vessels are hard to see, can the author zoom in further?
Results & Discussion
"The diameter of the mLVs was determined from successive 3D-T2-FLAIR images of the superior region shown in Figure 1B to be 700 ± 300 µm and at the occipital region based on the 2D-T2 images to be 800 ± 300 µm. This is in general agreement with the results of Goodman et al. who determined the diameter of mLVs from extracted human meningeal samples to be 354 ± 55 µm (healthy adults) and 381 ± 76 (subjects with Alzheimer's disease) within a range of 19 to 470 µm." How are these in good agreement? the values reported here are more than double of those reported in ref#17?? please discuss.
Conceptual advance and Impact8
The authors aimed to provide further evidence of the possibility to detect mLVs in vivo with MRI in humans. With MR images from one subject, the authors managed to detect mLVs in the MR images, which was in line with previous efforts. This observation is worth to publish. I have no further comments on the report.