Peer-reviewed by 2 reviewers with median rating of 13.5/20. Review process was triple-blinded.
Round 1 (13.5/20)
Conceptual advance and Impact7
Interesting single point observation, worth publishing.
Could modify the title slightly to be a little clearer. Instead of strong synergy, could use something like "synergistic toxicity due to....."
minor comment.....the very light blue, green and yellow lines/text are difficult to see/read. Please use a darker shade of color.
The evidence that glyphosate strongly induces oxidative stress in yeast is weak. Do modify second paragraph accordingly.
Results & Discussion
minor point: only oxidative stress due to H2O2 has been measured in this study, not other forms of oxidative stress. Do keep discussion to this point.
Conceptual advance and Impact5
An interesting ecotoxicological observation of synergistic interaction between commonly used herbicide glyphosate and industrial pollutant DNP that has implications in agriculture and landscaping environments. Use of yeast model to study this interaction will help in elucidating molecular mechanisms of this cocktail effect.
"...up to 8.1 mg/kg and up to mg/L levels respectively, ." missing value for mg/L?
"...yeast culture medium and incubted 30 minutes in the dark..." should be "...yeast culture medium and incubated 30 minutes in the dark..."