Plasma-surface modification (PSM) remains an effective technique to alter the surface of inorganic materials, and there is a growing interest in its application on organic materials. To date, research on the use of PSM to promote surface changes of organic materials has focused largely on experiments using aqueous solutions, particularly as they relate to end-use applications in pharmacological development. The purpose of this study is to explore the impact of PSM on dry protein powder, as it relates to surface area. Brunauer-Emmett-Teller (BET) theory analysis was performed to measure the surface area of both a pristine sample of whey protein isolate and a sample of whey protein isolate exposed to atmospheric plasma. In this study, we demonstrate that PSM can successfully increase the surface area of protein powder. Such changes in protein surface area, when delivered at an economical and commercial scale, may prove beneficial to food and nutrition applications.