The authors claim to show through a method that has been previously used for a different protein that residues involved in different classes of pathogenic G6PD mutation spatially correlate differently, with class I on the dimer interface and class II on tetramer interface. There is no clear discussion on how this correlates with function. There are a few flaws, first it looks like one of the central assumptions is that there are no changes in the monomer structure upon mutation. Second, although the method is explained, it is not clear. Third, while the finding looks interesting, with mutations neatly correlating with phenotype classes, it is not clear what the novelty of the finding is.