1)Add reference here, and remove "which ... (not shown)": This pattern is similar to the previously reported reduction in TERT mRNA levels during cortex development ,which was also confirmed in our experiments (not shown).
2) Remove "The specificity of the DNA-bound protein extracts was also confirmed by the lack of topo1 activity in the CHAPS extract and its existence in the CHAPS+NaCl extract (data not shown)"
3) Figure 1F (left graph, TERT activity) is a single experiment? If so I recommend repeating it 2x more and add the corresponding error bars and statistical significance.
4) Please remove " This telomerase activity inhibition effect of the DNA-bound embryonic brain extract was verified by mixing it with embryonic stem cell and cancer cell whole cell protein extract as well (data not shown)."
5)"The observation that TERT protein expression is maintain(ED) -> correct past tense!! through adulthood while its activity is significantly reduced was reported by previous reports (Klapper 2001) (Flanary 2003) (Mattson 2001) (Eitan 2012)."
6) Figure 1G - I are the most important for this observation, and they suggest not only the presence of an inhibitor but also that in old-D extracts there is a small increased activity, if the authors would like to comment on it. I think this is suitable for publication in matters, pending small revisions above.